Ximena Sariñana was born in Guadalajara and raised in Mexico City. She took up piano lessons with Hanna Cot. In 1994, Sariñana acted in the film, Hasta morir, which was produced by her father, Fernando Sariñana. Ximena was educated at the Academia de Musica Fermatta, a performing arts school and Edron Academy.
She began her acting career at 11 as the villain, Mariela, in the popular Mexican telenovela Luz Clarita. The following years, Sariñana acted in the telenovela María Isabel and in Gotita de amor. Other important movies in which she acted were El segundo aire, Niñas mal, Amar te duele and, Dos abrazos, with which she won an award for Best Female Actress at the 38th Diosas de Plata of PECIME awards. Sariñana returned to acting, appearing in the short film Gonzalo.
In September 2014, she was revealed as one of the judges for the reality talent show competition, México tiene talento, the Mexican version of America's Got Talent.